The interaction study of phosphatidylcholine multilamellar liposomes with lipid monolayer of phosphatidylcholine and cholesterol, is used as biophysical model in order to understand the mechanisms involved in liposcme-membrane cell interaction. Proposed theoretical treatment reveal a first order kinetic model for the experiences made at low surface pressure and the observed slight disagreement with general equation at higher initial surface pressure is also discussed and suggest posterior studies reproducing physiological conditions.