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TOPOCHEMICALLY RELATED HORMONE STRUCTURES: Synthesis of Partial Retro‐Inverso Analogs of LH‐RH

 

作者: NISHITH CHATURVEDI,   MURRAY GOODMAN,   CYRIL BOWERS,  

 

期刊: International Journal of Peptide and Protein Research  （WILEY Available online 1981）
卷期: Volume 17, issue 1  

页码: 72-88

 

ISSN:0367-8377

 

年代: 1981

 

DOI:10.1111/j.1399-3011.1981.tb01970.x

 

出版商: Blackwell Publishing Ltd

 

关键词: α,α‐g‐diaminoalkyl residues;luteinizing hormone‐releasing hormone (LH‐RH) analogs;peptide synthesis;retro‐inverso isomers;topochemical equivalents

 

数据来源: WILEY

 

摘要:

The syntheses of five partial retro‐inverso luteinizing hormone‐releasing hormone (LH‐RH)analogs, [g‐Tyr5, m‐Gly6]LH‐RH, [g‐Tyr5‐r‐Gly6, R,S‐m‐Leu7]LH‐RH, [g‐p‐Glu1, m‐His2]LH‐RH, [g‐p‐Glu1‐r‐D‐His‐R,S‐m‐Trp3]LH‐RH, and [g‐Pro9‐ propionyl‐des‐Gly10]LH‐RH, have been accomplished by solution methods. The choice of sequence to be reversed was based on suggested biodegradation mechanisms of LH‐RH. A (gem)‐diamino alkylidene residue, which was produced via Curtius rearrangement of a peptide segment, and a 2‐substituted malonyl residue mark the initia

 

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