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Concentrations of methicillin in blood, normal milk and mastitic milk of cows after intramuscular injection of methicillin and tamethicillin

 

作者: G. ZIV,   S. SOBACK,   A. BOR,  

 

期刊: Journal of Veterinary Pharmacology and Therapeutics  （WILEY Available online 1983）
卷期: Volume 6, issue 1  

页码: 41-47

 

ISSN:0140-7783

 

年代: 1983

 

DOI:10.1111/j.1365-2885.1983.tb00453.x

 

出版商: Blackwell Publishing Ltd

 

数据来源: WILEY

 

摘要:

Tamethicillin (TAM) is a basic ester pro‐drug of methicillin (MET) which is converted in the body by non‐specific esterases to MET. Equal doses of MET and TAM were administered intramuscularly in a crossover trial involving four dairy cows. Acute mastitis was induced in each cow by infusing two quarters of the udder withEscherichia coliendotoxin 3 h before antibiotic administrat

 

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