Self-Healing Epitheliomata of Ferguson-Smith: Cytogenetic and Histological Studies, and the Therapeutic Effect of Etretinate
作者:
Andrew L. Wright,
David J. Gawkrodger,
William A. Branford,
Kathryn McLaren,
John A.A. Hunter,
期刊:
Dermatology
(Karger Available online 1988)
卷期:
Volume 176,
issue 1
页码: 22-28
ISSN:1018-8665
年代: 1988
DOI:10.1159/000248665
出版商: S. Karger AG
关键词: Self-healing squamous cell carcinomata;Syringoma;Cryotherapy;Etretinate;DNA repair studies
数据来源: Karger
摘要:
212 epitheliomata developed in two unrelated women with self-healing epitheliomata of Ferguson-Smith. Most of the lesions appear on the face, often in crops; they enlarge over 4 weeks and, without treatment, resolve over 4 months to leave a ragged scar. One of the patients developed an unusual syringoma, a papillary carcinoma of the thyroid and a mucosal squamous cell carcinoma which failed to involute spontaneously. Cytogenetic studies did not reveal any abnormality of DNA repair. Surgical excision of the epitheliomata is successful but time consuming. X-irradiation should not be used, but cryotherapy of early lesions is helpful. One patient, treated with etretinate for 24 months, has developed only 8 epitheliomata over this time, compared with 23 in the previous 24 months. Etretinate therefore appears to prevent new lesions from developing.
点击下载:
PDF
(2057KB)
返 回