AbstractA new method of synthesis of some derivatives of 2‐methylchromone with possible physiological activity similar to kellin and visnagin but not containing the furan ring has been reported. Starting from 2‐hydroxy‐6‐methoxy‐acetophenone, 5‐methoxy‐2‐methylchromone has been obtained by way of the intermediate, 2‐hydroxy‐6‐methoxy‐ω‐acetylacetophenone. By alkaline persulphate oxidation, 5‐hydroxy‐2‐methylchromone is converted into 5,8‐dihydroxy‐2‐methylchromone. Its acetate, partial and complete methyl ethers have been obtained. Demethylation of 5,8‐dimethoxy‐2‐methylchromone gave the isomeric 5,6‐dihydroxy‐2‐methylchromone, the constitution of w