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Altered irinotecan metabolism in a patient receiving phenytoin

 

作者: Ron Mathijssen,   Alex Sparreboom,   Herlinde Dumez,   Allan van Oosterom,   Ernst de Bruijn,  

 

期刊: Anti-Cancer Drugs  （OVID Available online 2002）
卷期: Volume 13, issue 2  

页码: 139-140

 

ISSN:0959-4973

 

年代: 2002

 

出版商: OVID

 

关键词: Irinotecan;metabolism;phenytoin

 

数据来源: OVID

 

摘要:

The systemic exposure to the anticancer agent irinotecan (CPT-11) and its active metabolite SN-38 were 79 and 92% reduced, respectively, relative to literature data, by concomitant phenytoin therapy. This finding suggests that increased doses of CPT-11 should be given to patients treated simultaneously with these drugs, to achieve adequate levels of SN-38.

 

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