&NA;From 1976 to 1986, 681 patients with drug‐refractory trigeminal neuralgia (TN)—typical in 641, symptomatic of multiple sclerosis in 23 and of tumor in 10, atypical in 5, and postherpetic in 2—were treated with various percutaneous procedures. Controlled differential thermocoagulation of the gasserian ganglion and/or retrogasserian rootlets was performed in 533 patients; glycerolization of the trigeminal cistern in 32; and compression of the gasserian ganglion by balloon catheter in 159, Results and complications of each procedure are assessed at a mean follow‐up of 6.5 years for thermocoagulation, 5 years for glycerolization, and 3.5 years for compression. The following therapeutic protocol is proposed: 1) in TN patients at first operation:a) gasserian compression (or glycerolization, if experience warrants it) is indicated in all cases of typical TN, unless the 3rd division alone is affected;b) in the latter case and in symptomatic TN, we suggest thermocoagulation; 2) in recurrences:a) after glycerolization or gasserian compression, gasserian compression (or glycerolization) is indicated;b) after thermocoagulation or open surgery, thermocoagulation is suggested. (Neurosurgery24:239‐245, 1989)