Eye enucleation alters intracellular distribution of NO synthase in the superior colliculus
作者:
Frank Tenório,
Arthur Giraldi-Guimarães,
Hélio Santos,
Wagner Cintra,
Rosália Mendez-Otero,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 1
页码: 145-148
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Activity dependence;Development;Eye enucleation;Nitric oxide synthase;Superior colliculus;Visual system
数据来源: OVID
摘要:
WE investigated the role of retinotectal projections on the distribution of nitric oxide synthase (NOS) in the retinoceptive layers of the rat superior colliculus (SC) using histochemical methods. Rats enucleated at birth showed no alteration in the temporal pattern of NOS expression. There was, however, a dramatic change in the NADPH-diaphorase staining pattern of NOS-positive cells. NOS was absent from the distal portions of the dendritic trees of the deafferented SC. Nevertheless, staining the dendritic trees of these cells with Lucifer yellow showed that they were not morphologically different from those of the ipsilateral SC of monoenucleated animals. The same results were obtained when enucleation was performed in adult rats. We conclude that NOS intracellular distribution in the SC cells can be regulated by retinotectal projections in both developing and adult animals.
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