The incidence of intraoperative anaphylactic reactions has been estimated to be between 1 in 1,500 and 1 in 5,000; approximately 5 to 10% of patients developing intraoperative anaphylaxis die as a direct result [1]. Triggering agents implicated in these reactions include neuromuscular blocking drugs, intravenous anesthetics, intraoperative antibiotics, radiocontrast material, blood products, and protamine. No etiology is identified, however, in approximately 16% of these cases [2]. In the past 10 years, case reports have been published in the literature linking latex exposure to severe, immediate, type I allergic reactions in the operating room [3]. At present, this linkage is inferred and direct proof is lacking. However, latex-mediated immune reactions appear to be real and warrant consideration whenever unexplained anaphylactic or allergic reactions occur in the operating room.