Free postsynaptic densities in the hippocampus of the female rat
作者:
Nancy Desmond,
William Levy,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 9
页码: 1975-1979
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: CA1;Estrogen;Female;Free PSD;Hippocampus;PSD;Synapse elimination;Synaptogenesis
数据来源: OVID
摘要:
THE number of synapses in the adult, female hippo-campal CA1 region fluctuates naturally across the estrous cycle in an ovarian steroid-dependent manner. This phasic variation in synapse number occurs without identifiable degenerating synapses. Ultrastructural correlates of the dynamic aspect of this synapse loss and synapse formation thus remain undescribed. During early development, one hallmark of synaptogenesis is the presence of free postsynaptic densities (PSDs). Here we report that the incidence of free PSDs in CA1 fluctuates across the rat estrous cycle. The number of free PSDs is greatest on the afternoon of proestrus and is significantly decreased on the afternoon of estrus, 24 h later. We hypothesize that these free PSDs reflect synapse turnover in the adult CA1 region.
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