Response of Calcitonin-Gene-Related Peptide-Like Immunoreactive Nerve Fibers of the Anterior Pituitary to Adrenalectomy in the Rat
作者:
Gong Ju,
Dan Ma,
Si-Chang Fan,
期刊:
Neuroendocrinology
(Karger Available online 1994)
卷期:
Volume 59,
issue 5
页码: 505-510
ISSN:0028-3835
年代: 1994
DOI:10.1159/000126697
出版商: S. Karger AG
关键词: Calcitonin-gene-related peptide;Innervation;Anterior pituitary;Adrenalectomy
数据来源: Karger
摘要:
The mammalian anterior pituitary is known to be regulated by humoral factors only, no direct neural influence having ever been discovered. Our recent studies have shown in several species that there are substantial amounts of substance P and calcitonin-gene-related peptide-like immunoreactive (CGRP-LI) nerve fibers in the anterior pituitary and that they can make synaptic contacts with secretory cells, among which corticotropes. In the present study, we investigated changes in CGRP-LI nerve fibers of the anterior pituitary after bilateral adrenalectomy in the rat. The results show that the number of CGRP-LI nerve fibers increases significantly. In parallel, they cover a wider area of the gland after the operation, suggesting a direct neural influence.
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