Correlation Between Surrogate Markers, Viral Load, and Disease Progression in HIV‐1 Infection
作者:
A. Lafeuillade,
C. Tamalet,
P. Pellegrino,
Ph de Micco,
C. Vignoli,
R. Quilichini,
期刊:
Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1994)
卷期:
Volume 7,
issue 10
页码: 1028-1033
ISSN:0894-9255
年代: 1994
出版商: OVID
关键词: HIV infection;Acquired immune deficiency syndrome;Prognosis;Quantitative viremia;β2-microglobulin;Neopterin;Thymidine kinase;p24 Antigenemia
数据来源: OVID
摘要:
Surrogate markers generally used for observation of patients infected with human immunodeficiency virus (HIV) and their plasma and cellular viral load were assayed in a series of 40 patients before initiation of zidovudine therapy. Plasma viremia was positive in 62.5% of patients and was statistically correlated with clinical stage, CD4+T cell count, CD8+T cell count, β2-microglobulin level, neopterin level, and immunoglobulin A level. Cellular viremia was positive in 95% of patients and was correlated with clinical stage, CD4+T cell count, β2-microglobulin, neopterin levels, and disease progression during the following months. A discordance was found between p24 antigenemia, even after acid dissociation of immune complexes, and plasma viremia. In fact, p24 antigenemia was correlated with only biological markers of immune activation as β2-microglobulin and neopterin levels. The measurement of anti-p24 antibodies did not appear discriminative in our staging. Plasma viremia, like CD4+T cell count, reflects the patient's status at the time of assessment. Cellular viremia could be more informative for the prediction of future clinical progression.
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