Rapid Communication:Acute Renal Failure Associated with Tenofovir: Evidence of Drug-Induced Nephrotoxicity
作者:
Steven Coca,
Mark Perazella,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 2002)
卷期:
Volume 324,
issue 6
页码: 342-344
ISSN:0002-9629
年代: 2002
出版商: OVID
关键词: Acute renal failure;Tenofovir;HIV;AIDS;Antiviral therapy
数据来源: OVID
摘要:
Drug-induced renal failure is a relatively common event in patients infected with HIV. This group of patients receives a number of potentially nephrotoxic medications for a variety of illnesses. The acyclic nucleoside phosphonates cidofovir and adefovir are antivirals that possess significant nephrotoxicity. Interestingly, tenofovir disoproxil fumurate (DF) is structurally similar to these 2 agents, yet seems to be less nephrotoxic based on a few published studies in HIV patients with intact renal function. We present a case in which acute renal failure developed after therapy with tenofovir DF in a patient with HIV and stable chronic kidney disease.
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