HIV Antigen Variability in ARC/AIDS
作者:
Craig Hendrix,
Paul Volberding,
Richard Chaisson,
期刊:
Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1991)
卷期:
Volume 4,
issue 9
页码: 847-850
ISSN:0894-9255
年代: 1991
出版商: OVID
关键词: HIV antigen;p24 antigen;Antiviral therapy;Sample size.
数据来源: OVID
摘要:
Summary:To define the natural variability of human immunodeficiency virus p24 antigen (HIV Ag) over time in untreated HIV-infected patients, we analyzed the percentage change of serum HIV Ag in 40 antigenemic ARC/AIDS subjects receiving placebo in a 24 week clinical trial. When grouped by month of observation, no differences in HIV Ag change were seen among all five 1 month observation periods (p> 0.4). After all 105 monthly changes (medialn of 3 per subject) were pooled, the mean monthly HIV Ag change was 0% change (standard deviation: 77% increase, 44% decrease). Furthermore, HIV Ag changes did not differ among all lengths of observation (from 1 to 5 months using all possible pairwise combinations of HIV Ag levels,p> 0.4). CD4 T-cell changes over the whole study did not correlate with HIV Ag changes over the same period. Knowledge of this broad HIV Ag variability should be useful in calculating sample size and in choosing categorical responses unlikely to occur spontaneously in clinical trials of antiviral agents where HIV Ag changes are used as surrogate markers of efficacy.
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