Mutagenicity and chemical analysis of aliphatic and aromatic fractions of prudhoe bay crude oil and fuel oil no. 2
作者:
JenniferA. Ellenton,
DouglasJ. Hallett,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1981)
卷期:
Volume 8,
issue 5-6
页码: 959-972
ISSN:0098-4108
年代: 1981
DOI:10.1080/15287398109530130
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The mutagenicity of aliphatic (fraction J), one‐ to three‐ring aromatic (fraction 3), and four‐ to five‐ring aromatic (fraction 4) fractions of Prudhoe Bay crude oil and of a fuel oil no. 2 was investigated with a battery of in vitro mammalian and microbial assays. Chemical analysis of the fractions was carried out by gas capillary chromatog‐raphy‐mass spectrometry. In the Salmonella/mammfl//a/7 microsome test, both first fractions were negative, while fraction 3 of Prudhoe Bay crude and fraction 4 of both oils exhibited mutagenic activity with metabolic activation. In Chinese hamster ovary cells, all of the aromatic fractions, in the presence of metabolic activation, caused a significant increase in the number of sister chromatid exchanges. Chromosome aberrations were not caused by any of the aromatic fractions; however, fraction 3 of fuel oil no. 2 induced endoreduplication in the presence of metabolic activation.
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