MK‐801 reinstates drug‐seeking behaviour in cocaine‐trained rats
作者:
Taco De Vries,
Anton Schoffelmeer,
Rob Binnekade,
Arie Mulder,
Louk Vanderschuren,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 4
页码: 637-640
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Cocaine;Craving;Drug-seeking behaviour;Intravenous self-administration;MK-801;NMDA receptors;Reinstatement
数据来源: OVID
摘要:
WE evaluated the incentive motivational properties of MK-801 by determining its priming effect on drug-seeking behaviour following extinction of cocaine self-administration, an animal model for drug craving. Rats were allowed to self-adminstrate cocaine (0.5mg/kg) or saline during 10 daily sessions. MK-801 (0.1–0.52mg/kg, i.p.) dose-dependently reinstated responding for cocaine following an extinction period of 3 weeks. Responding was selectively enhanced in the previously drug-paired hole and was completely absent in rats with a history of saline self-administration. These data provide evidence for a possible role of NMDA receptors in the incentive motivation underlying cocaine-seeking behaviour. In addition, the ability of MK-801 to elicit drug-seeking behaviour may prove to be a serious drawback for the proposed use of NMDA antagonists in the treatment of drug addiction.
点击下载:
PDF
(309KB)
返 回