Stevens–Johnson syndrome/toxic epidermal necrolysis in a patient receiving concurrent radiation and gemcitabine
作者:
Karen Sommers,
Kevin Kong,
Dang Bui,
John Fruehauf,
Randall Holcombe,
期刊:
Anti-Cancer Drugs
(OVID Available online 2003)
卷期:
Volume 14,
issue 8
页码: 659-662
ISSN:0959-4973
年代: 2003
出版商: OVID
关键词: chemotherapy toxicity;gemcitabine;radiation;Stevens–Johnson Syndrome;toxic epidermal necrolysis
数据来源: OVID
摘要:
A patient with stage IV malignant melanoma treated with daily radiotherapy and low-dose (100 mg/m2) daily gemcitabine developed a blistering skin eruption, fever and neutropenia consistent with overlap Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). The diagnosis was confirmed by skin biopsy of an affected area. The case history is described, and the literature relating to the development of SJS/TEN in association with chemotherapy and radiotherapy administration is reviewed. This report describes a serious potential complication of concurrent gemcitabine and radiotherapy.
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