Effects of gestational exposure to tordon 202c on fetal growth and development in CD‐1 mice
作者:
PatriciaM. Blakley,
JinSuk Kim,
GayD. Firneisz,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1989)
卷期:
Volume 28,
issue 3
页码: 309-316
ISSN:0098-4108
年代: 1989
DOI:10.1080/15287398909531351
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The teratogenic effects of Tordon 202c, a picloram and 2,4‐D combination formulation, are unknown. Pregnant CD‐1 mice were exposed to Tordon 202c in the drinking water at concentrations of 0.10, 0.21, and 0.42% from d 6 to 15 of gestation. Fetal growth parameters, including body weight and crown‐rump length, were reduced in a dose‐dependent manner, as was placental weight. The incidence of dead fetuses/ resorptions and malformed fetuses (especially cleft palate) was increased in the highest dosage group. A subtle indication of maternal toxicity was noted in the highest dosage group as evidenced by decreased water consumption and increased relative liver weight. The present study suggests that Tordon 202c is embryotoxic and teratogenic in CD‐1 mice when administered during organogenesis.
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