NMR Studies of Drugs. Enantiomeric Excess Determination ofN-acetylcathinone with Eu(HFC)3
作者:
Ronnie Benshafrut,
Robert Rothchild,
期刊:
Spectroscopy Letters
(Taylor Available online 1992)
卷期:
Volume 25,
issue 7
页码: 1097-1120
ISSN:0038-7010
年代: 1992
DOI:10.1080/00387019208018219
出版商: Taylor & Francis Group
关键词: Cathinone;Khat (qat);Optical Purity;Chiral Lanthanide Shift Reagent;LSR;Europium;α-Aminopropiophenone;Stereoisomer;NMR Shift reagent;Analysis
数据来源: Taylor
摘要:
A technique for determination of enantiomeric excess of cathinone, 2-amino-1-phenyl-1-propanone, by use of the chiral lanthanide shift reagent (LSR), tris[3-(heptafluoropropylhydroxymethylene)-d-camphorato]europium (III), Eu (HFC)3, is described. The hydrochloride salt of the cathinone sample is first converted directly to theN-acetyl derivative without need for isolation of the potentially unstable cathinone free base. Addition of Eu (HFC)3to the crude acetylated cathinone resulted in near-baseline resolution of theCH3CO resonances of the enantiomers. Analytical utility and the sense of magnetic nonequivalence of this signal were demonstrated using “spiked” non-racemic samples.
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