Suppressive Effect of Superoxide Dismutase on Adriamycin Nephropathy
作者:
Teruo Okasora,
Takako Takikawa,
Yasushi Utsunomiya,
Isonori Senoh,
Hiroshi Hayashibara,
Kazuo Shiraki,
Tsunakiyo Kasagi,
Fujio Shimizu,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 60,
issue 2
页码: 199-203
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186739
出版商: S. Karger AG
关键词: Adriamycin nephropathy;Oxygen free radical scavenger;Superoxide dismutase
数据来源: Karger
摘要:
A single intravenous injection of adriamycin (ADR) results in marked proteinuria and glomerular morphological changes that are similar to minimal-change disease in humans. We examined the effect of superoxide dismutase (SOD) on ADR-induced proteinuria. ADR in a dose of 7.5 mg/kg body weight significantly increased urinary protein by day 14; proteinuria rapidly increased thereafter. Concurrent administration of SOD (50 mg/kg) over 30 min prior to and 30 min following ADR injection markedly reduced proteinuria. Twenty-one days after the treatment with SOD, the amount of urinary protein was 108.6 ± 43.1 mg/24 h in the experimental animals, while it was 221.6 ± 102.9 mg/24 h in the ADR control group (p < 0.05). There were also less severe glomerular morphologic changes in the SOD group versus ADR controls. The protective effects of SOD provide indirect evidence that oxygen free radicals are important mediators of ADR-induced proteinuri
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