HIV‐2-induced immunosuppression among asymptomatic West African prostitutesevidence that HIV‐2 is pathogenic, but less so than HIV‐1
作者:
Jacques Pepin,
Gareth Morgan,
David Gevao,
Maimuna Mendy,
Isatou Gaye,
Nora Scollen,
Richard Tedder,
Hilton Whittle,
期刊:
AIDS
(OVID Available online 1991)
卷期:
Volume 5,
issue 10
页码: 1165-1172
ISSN:0269-9370
年代: 1991
出版商: OVID
关键词: HIV-2;HIV-1;HTLV-I;CD4 + lymphocytes;pathogenicity;CD25 + lymphocytes;activated lymphocytes;West Africa;The Gambia.
数据来源: OVID
摘要:
Two hundred and forty-one prostitutes working in The Cambia were tested for retroviral infections and their immune system evaluated. Sixty-three were seropositive for HIV-2 only, five for HIV-1 only and six for both HIV-1 and HIV-2 (26.1, 2.1 and 2.5%, respectively). When compared to seronegative individuals, the 63 women infected with HIV-2 clearly had an abnormal immune system, with significantly lower CD4 + and higher CD8 + lymphocyte counts and percentages, lower CD4 +: CD8 + ratios, lower CD25 + (activated) lymphocyte counts, and lower lymphocyte proliferation responses after stimulation with phytohaemagglutinin, purified protein derivative (PPD),Candidaor pokeweed mitogen, and higher levels of neopterin and β2-microglobulin. However, when the HIV-2-seropositive prostitutes were compared with the five women infected with HIV-1, the former were less abnormal, with significantly higher CD4 + percentages and CD4+: CD8+ ratios and lower CD8 + percentages and counts. Immunological anomalies were seen in five women known to have been infected with HIV-2 for <17 months. Coinfection with HTLV-I resulted in more severe immunological alterations than infection with HIV-2 alone.
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