The precipitation of fine aqueous droplets as “haze” or entrainment in dodecane solutions of di-2-ethylhexylsulfoxide (DEHSO) is demonstrated in experiments in which water-saturated dodecane solutions of DEHSO are diluted with water-saturated dodecane at 25 °C. The resulting turbidity correlates with the concentration of excess water predicted from an analysis of the water extraction behavior of DEHSO. Underlying the dilution-induced turbidity is the destabilization of dimer hydrates (DEHSO)2(H2O)n, causing the release of water to the solvent. Other neutral oxygen-donor extractants are expected to exhibit this effect, which may provide additional insight into the appearance of turbidity and associated problems in certain solvent extraction systems.