Pharmacological testing in the laser-induced monkey glaucoma model
作者:
YuPing,
PodosSteven M.,
HowardJulia R.,
SeverinColette H.,
RoseAron D.,
SiegelMarc J.,
期刊:
Current Eye Research
(Taylor Available online 1985)
卷期:
Volume 4,
issue 7
页码: 775-781
ISSN:0271-3683
年代: 1985
DOI:10.3109/02713688509020033
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Glaucoma was induced in cynomolgus monkeys by photocoagulating the trabecular meshwork with the argon laser. Repeat treatments were often necessary and wide intraocular pressure fluctuations were characteristic.Baseline intraocular pressure was measured with a calibrated pneumatonometer hourly for six hours. On a succeeding day a baseline measurement was made, 50μl of the drug to be tested applied, and six hourly measurements of intraocular pressure repeated. The effects on intraocular pressure of timolol, epinephrine, pilocarpine, vanadate, prostaglandin F2α(PGF2α), forskolin, and corynanthine were tested in at least eight eyes. Significant (p<0.05) reductions of intraocular pressure were produced by 0.5% timolol, 2% epinephrine, 4% pilocarpine, 1% vanadate, 500μg of PGF2αand 1% forskolin. Five per cent corynanthine produced no significant lowering of intraocular pressure.Tonography revealed an increased outflow facility associated with the reduction of intraocular pressure 2 hours after the administration of 4% pilocarpine.This glaucoma animal model may be useful in investigating agents that lower intraocular pressure by a variety of mechanisms.
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