Dynamic Effects of Carotid Sinus Baroreflex on Ventriculoarterial Coupling Studied in Anesthetized Dogs
作者:
Toru Kubota,
Joe Alexander,
Ryoichi Itaya,
Koji Todaka,
Masaru Sugimachi,
Kenji Sunagawa,
Yoshiaki Nose,
Akira Takeshita,
期刊:
Circulation Research
(OVID Available online 1992)
卷期:
Volume 70,
issue 5
页码: 1044-1053
ISSN:0009-7330
年代: 1992
出版商: OVID
关键词: carotid sinus baroreflex;ventriculoarterial coupling;end-systolic elastance;effective arterial elastance;transfer function
数据来源: OVID
摘要:
We evaluated dynamic effects of the carotid sinus baroreflex on ventriculoarterial coupling. In seven anesthetized, vagotomized dogs, we bilaterally isolated carotid sinuses and randomly changed carotid sinus pressure while measuring aortic pressure, aortic flow, and left ventricular pressure. Estimating left ventricular end-systolic elastance (Ees) and effective arterial elastance (Ea) on a beat-to-beat basis, we determined transfer functions from the carotid sinus pressure to Ees(HEes) and from the carotid sinus pressure to Ea(HEs) over the frequency range spanning 0.002–0.25 Hz. Both HEes, and HEaexhibited characteristics of a second-order low-pass filter. The gains of HEesand HEawere 0.085 ± 0.065 (mean ± SD) and 0.081 ± 0.049 mm Hg/ml/mm Hg, respectively. There were no significant differences in natural frequencies (0.039 ± 0.013 versus 0.039 ± 0.007 Hz) or damping ratios (0.65 ± 0.11 versus 0.64 ± 0.24). The results indicated that the carotid sinus baroreflex dynamically altered Eesand Eato the same extent in the process of stabilizing arterial pressure. Because the arterial system extracts maximal external work from a given heart when Eaequals Ees, the carotid sinus baroreflex appeared to be designed to regulate the ventricular and arterial properties to optimize the energy transmission from the left ventricle to the arterial system in anesthetized, vagotomized dogs. (Circulation Research1992;70:1044–1053)
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