Determination of adriamycin and its fluorescent metabolites in human plasma by HPLC
作者:
R. Mahdadi,
M. Lhermitte,
J. J. Lafitte,
期刊:
Biomedical Chromatography
(WILEY Available online 1987)
卷期:
Volume 2,
issue 1
页码: 38-40
ISSN:0269-3879
年代: 1987
DOI:10.1002/bmc.1130020111
出版商: John Wiley&Sons, Ltd.
数据来源: WILEY
摘要:
AbstractWe describe a method for measuring adriamycin and its metabolites, adriamycinol and adriamycinone in plasma, using reversed phase HPLC and fluorescence detection. The lower limit of detection is approximately 1 ng/mL for each compound. An extraction technique for serum is described which is capable of an almost equal recovery (>93%) of adriamycin and metabolites without interference from endogenous components of plasma and from other common drugs. Within‐day and day to day coefficients of variation are estimate
点击下载:
PDF
(269KB)
返 回