Lack of RH C/E expression in the Rhesus D– phenotype is the result of a gene deletion
作者:
T. BLUNT,
F. STEERS,
G. DANIELS,
B. CARRITT,
期刊:
Annals of Human Genetics
(WILEY Available online 1994)
卷期:
Volume 58,
issue 1
页码: 19-24
ISSN:0003-4800
年代: 1994
DOI:10.1111/j.1469-1809.1994.tb00722.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
SUMMARYWe have investigated the arrangement of genes in the rare Rh (Rhesus) partial null condition D–, Southern blot and PCR studies under conditions which distinguish the highly homologous RH D and RH C/E genes show that in an Icelandic family with the D– haplotype at least 85% of the RH C/E gene is deleted. This finding is in contrast to one other published case of this phenotype, where intact RH D and C/E genes were found, and also to the full amorph Rhnullphenotype, where an intact RH C/E gene was found, accompanied by the deletion of the RH D gene typical of Rh D‐negative indivi
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