Abnormal Membrane Fluidity as a Cause of Impaired Functional Dynamics of Chemoattractant Receptors on Neonatal Polymorphonuclear LeukocytesLack of Modulation of the Receptors by a Membrane Fluidizer
作者:
KOZO YASUI,
MIDORI MASUDA,
TAKAFUMI MATSUOKA,
MUNEHIRO YAMAZAKI,
ATSUSHI KOMIYAMA,
TARO AKABANE,
MASAFUMI HASUI,
YOHNOSUKE KOBAYASHI,
KENJIRO MURATA,
期刊:
Pediatric Research
(OVID Available online 1988)
卷期:
Volume 24,
issue 4
页码: 442-446
ISSN:0031-3998
年代: 1988
出版商: OVID
数据来源: OVID
摘要:
Membrane properties associated with chemoattractant-mediated cellular responsiveness of neonatal polymorphonuclear leukocytes (PMN) were analyzed using n-formylmethionyl-leucyl-phenylalanine. Inasmuch as aliphatic alcohols as a membrane fluidizer can enhance the chemoattractant binding and affect subsequent cellular responsiveness in adult PMN, neonatal PMN were studied for such properties by their treatment with iso-propyl alcohol, an aliphatic alcohol. The alcohol (p< 0.01). Although the aliphatic alcohol enhanced the membrane fluidity of adult PMN, it did not affect the membrane fluidity of neonatal PMN. We conclude that there is abnormal membrane fluidity as a cause of impaired functional dynamics of the chemoattractant receptors, which appears to underlie the defective modulation of cell functions by the membrane fluidizer in neonatal PMN. (Pediatr Res24: 442–446, 1988)
点击下载:
PDF
(535KB)
返 回