Recurrent neuroleptic malignant syndrome associated with inv dup(15) and mental retardation
作者:
Arthur L. Lazarus,
Kenneth E. Moore,
Nancy B. Spinner,
期刊:
Clinical Genetics
(WILEY Available online 1991)
卷期:
Volume 39,
issue 1
页码: 65-67
ISSN:0009-9163
年代: 1991
DOI:10.1111/j.1399-0004.1991.tb02987.x
出版商: Blackwell Publishing Ltd
关键词: inv dup(15);malignant hyperthermia;mental retardation;neuroleptic malignant syndrome
数据来源: WILEY
摘要:
Neuroleptic malignant syndrome (NMS) is an uncommon but serious adverse reaction to neuroleptic drugs. Clinically, it resembles malignant hyperthermia, a pharmacogenetic disorder of anesthesiology. Inv dup(15) is a rare but underrecognized cause of mental retardation among institutionalized patients. NMS and inv dup(15) have not been previously reported together. Their association should encourage clinicians to search for genetic markers for NMS.
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