Novel Metronidazole Membrane Sensor Based on a 2,6‐(p‐N,N‐Dimethylaminophenyl)‐4‐Phenylthiopyrylium Perchlorate
作者:
Mohammad Reza Ganjali,
Parviz Norouzi,
Farnoush Faridbod,
Hooshang Pirelahi,
期刊:
Journal of the Chinese Chemical Society
(WILEY Available online 2007)
卷期:
Volume 54,
issue 1
页码: 55-61
ISSN:0009-4536
年代: 2007
DOI:10.1002/jccs.200700010
出版商: WILEY‐VCH Verlag
关键词: Metronidazole sensor;PVC membrane;1‐(Beta‐hydroxyethyl)‐2‐methyl‐5‐nitroimidazole;2,6‐(p‐N,N‐dimethylaminophenyl)‐4‐phenylthiopyrylium perchlorate
数据来源: WILEY
摘要:
AbstractA novel PVC‐based membrane sensor based on 2,6‐(p‐N,N‐dimethylaminophenyl)‐4‐phenylthiopyrylium perchlorate (DAPP) is described. The electrode exhibits a sub‐Nernstian response to 1‐(beta‐hydroxyethyl)‐2‐methyl‐5‐nitroimidazole (metronidazol) over a relatively wide concentration range (1.0 × 10−1to 1.0 × 10−5M) with a detection limit of 8.0 × 10−6M. The best performance was obtained with the membrane containing 30% poly (vinyl chloride), 50% dibutyl phthalate, 7% DAPP and 13% oleic acid. It has a fast response time (<30 s) and can be used for at least four weeks without any major deviation. The proposed sensor revealed very good selectivity for metronidazole over a wide variety of common cations, anions and amino acids and could be used in the pH range of 6.0–7.5. It was successfully used for direct determination of metronidazole in an oral synthetic antiprotozoal as an antibacterial agent, in metronidazole tablets, and metronidazo
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