Effect of Interferon-γ on Biogenic Amine Metabolism, Electroencephalographic Recordings, and Transient Potentials
作者:
M. Färkkilä,
M. Iivanainen,
M. Härkönen,
J. Laakso,
K. Mattson,
A. Niiranen,
T. Larsen,
K. Cantell,
期刊:
Clinical Neuropharmacology
(OVID Available online 1988)
卷期:
Volume 11,
issue 1
页码: 63-67
ISSN:0362-5664
年代: 1988
出版商: OVID
关键词: Interferon-γ;Biogenic amine metabolism;5-Hydroxyindoleacetic acid;Homovanillic acid;Electroencephalography;Visual evoked potentials.
数据来源: OVID
摘要:
Summary:For assessment of the underlying central mechanisms of interferon (IFN), measurements have been made of the neurotoxicity, cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) concentrations, along with electroencephalographic (EEG) recordings and visual evoked potentials (VEP) during recombinant IFN-γ therapy. Interferon-γ was administered intravenously to 14 patients with non-small-cell lung cancer as 2 mg/m2(48 ± 106IU/m2) three times weekly with 4 h infusion for 12 weeks. The cerebrospinal fluid (CSF) samples were taken by means of lumbar puncture prior to treatment and during the end of the second week of IFN-γ infusions. During the course of treatment, CSF 5-HIAA diminished from 129.6 ± 10.9 to 84.5 ± 10.4 nmol/L (p < 0.001), while no significant changes were observed in HVA, EEG, and VEPs. These results suggest that IFN-γ has an effect on the central serotonergic neurotransmission.
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