Valproic Acid Disposition and Protein Binding in Pregnancy
作者:
Michael Koerner,
Mark Yerby,
Pat Friel,
Karen McCormick,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1989)
卷期:
Volume 11,
issue 3
页码: 228-230
ISSN:0163-4356
年代: 1989
出版商: OVID
关键词: Pregnancy;Valproic acid;Protein binding;Free levels.
数据来源: OVID
摘要:
Summary: Nine epileptic women were followed prospectively through pregnancy on a monthly basis. At each visit, total and free serum valproic acid levels and albumin levels were obtained. Assays were done by gas-liquid chromatography, and free drug was separated by ultrafiltration. Despite an upward dose adjustment in four patients, total valproic acid levels declined as pregnancy proceeded, but free levels did not. Plasma free fractions and clearances increased, but intrinsic clearances, which were adjusted for changes in body weight, remained unchanged.
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