Horse anti‐bovine lymphocyte serum. Its effect in calves1
作者:
W. Rumawas,
A. A. Ressang,
期刊:
Veterinary Quarterly
(Taylor Available online 1980)
卷期:
Volume 2,
issue 4
页码: 234-236
ISSN:0165-2176
年代: 1980
DOI:10.1080/01652176.1980.9693785
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Anti‐bovine lymphocyte serum (ABLS) had been prepared in horses with calf thymocytes as antigen and its effects in calves following parenteral administration were studied. The optimal dose was found to be one ml/kg body weight. The A BLS suppressed both the T and B cell functions. The former was indicated by the disturbed response to sheep erythrocytes injections, by the decreased number of spontaneous E rosette forming lymphocytes, the prolonged survival of skin allografts and the significant inhibition of the delayed hypersensibility skin reaction (tuberculination) following administrationof Mycobacterium microti.The latter was based on the disturbed response to a subcutaneous dose of tetanus toxoid. The reaction of lymphocytes of ABLS treated calves to phytohemagglutinin and poke weed mitogen was also inhibited. The disturbed reactions of the T and B cells might be among others based on the strong reduction of lymphocytes in the blood circulation by ABLS (up to 10–20%).
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