Migraine is a prevalent condition worldwide. It has far-reaching individual and societal economic impact. Almost all migraineurs (95%) take medications for headache relief and the majority use over-the-counter (OTC) medications. OTC drugs are readily accessible, affordable and effective. These medications are commonly used without the advice of a healthcare professional, hence the potential for negative health outcomes due to improper use. To avoid these problems and their potentially harmful consequences (e.g. toxicity, adverse effects), major efforts should be directed towards educating the public about migraine and its treatment, including the appropriate use of OTC medications.