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Genotypic analysis using a Y‐chromosome‐specific probe following bone marrow transplantation

 

作者: Hiroko Morisaki,   Takayuki Morisaki,   Yutaka Nakahori,   Hiromi Ogura,   Hitoshi Kanno,   Kenzaburo Tani,   Hideki Kodo,   Hisaichi Fujii,   Shigetaka Asano,   Shiro Miwa,  

 

期刊: American Journal of Hematology  （WILEY Available online 1988）
卷期: Volume 27, issue 1  

页码: 30-33

 

ISSN:0361-8609

 

年代: 1988

 

DOI:10.1002/ajh.2830270108

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

关键词: genotypic analysis;Y‐chromosome;probe;chimerism;bone marrow transplantation

 

数据来源: WILEY

 

摘要:

AbstractTo monitor successful engraftment after bone marrow transplantation, we performed Southern hybridization analysis or dot blot analysis of DNA in a set of sex‐mismatched cases using a Y‐chromosome‐specific DNA probe (pHY10). This method was extremely sensitive and rapid for checking which cells contain the Y‐chromosome. Using this probe, analysis of cells from peripheral blood and bone marrow after transplantation demonstrated the usefulness of confirming engraftment of donor cells and of detecting mixed lymphohematopoietic ch

 

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