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Parkinsonian Syndrome in Childhood After Sodium Valproate Administration

 

作者: M. Alvarez-Gomez,   J. Vaamonde,   J. Narbona,   M. Barao,   P. Barona,   T. Brannan,   M. Gudin,   R. Ibañez,  

 

期刊: Clinical Neuropharmacology  （OVID Available online 1993）
卷期: Volume 16, issue 5  

页码: 451-455

 

ISSN:0362-5664

 

年代: 1993

 

出版商: OVID

 

关键词: Juvenile parkinsonism;GABAergic neurotransmitters;Sodium valproate

 

数据来源: OVID

 

摘要:

SummaryAmong the side effects attributed to sodium valproate administration, the production of a parkinsonian syndrome is very uncommon, particularly in children. We report a 12-year-old girl with secondary epilepsy; 7 days after the initiation of valproate therapy she developed parkinsonism that disappeared completely when valproate was replaced by carbamazepine. We discuss the possible role of alterations in GABAergic neurotransmission in the extrapyramidal syndrome that developed.

 

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