Tocopherol (Vitamin E) in Alzheimer’s Disease and Other Neurodegenerative Disorders
作者:
Karen Berman,
Henry Brodaty,
期刊:
CNS Drugs
(ADIS Available online 2004)
卷期:
Volume 18,
issue 12
页码: 807-825
ISSN:1172-7047
年代: 2004
出版商: ADIS
关键词: Tocopherol, therapeutic use;Alzheimer's disease, treatment;Parkinson's disease, treatment;Tardive dyskinesia, treatment
数据来源: ADIS
摘要:
In this article, we review the evidence that tocopherol (vitamin E) may have a role to play in the prevention and treatment of Alzheimer’s disease and other neurological diseases. The theoretical rationale for the effectiveness of tocopherol as treatment and/or prevention of Alzheimer’s disease is based on its antioxidant properties. Results from animal andin vitrostudies provide evidence to support use of tocopherol for prevention and treatment of degenerative neurological diseases. Furthermore, several, but not all, epidemiological, cross-sectional, prospective studies indicate that tocopherol may have protective effects in Alzheimer’s disease, although dietary and supplemental forms of the vitamin may differ in their efficacy. Mixed results have been obtained from clinical trials. Evidence of the use of tocopherol as a protective measure or as therapy in neurological diseases other than Alzheimer’s disease is less compelling. To date, there are no clear-cut answers as to whether tocopherol is worth prescribing, but current clinical practice favours its use in the treatment of Alzheimer’s disease.
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