Two Pathways of Signal Transduction are Activated in the Same Cell by Different Cytokines
作者:
BartonBeverly E.,
MayerRosemary,
JacksonJames V.,
ClarkMike A.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1991)
卷期:
Volume 13,
issue 1-2
页码: 199-218
ISSN:0892-3973
年代: 1991
DOI:10.3109/08923979109019700
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractNFS60, a murine leukemia cell line, responds to both interleukin 3 and 6 by proliferating, apparently by different signal transduction pathways. Although stimulation by both cytokines increases the uptake of3H-arachidonic acid, the response to IL-6 was much faster. Furthermore, the effect of various arachidonic acid metabolites on the response to cytokine was different. PGE2 inhibited IL-6–induced proliferation and potentiated the response to IL-3. Additionally the G proteins which coupled the IL-3 and IL-6 receptor to the proliferative response are probably different, based on the ability of cholera toxin to inhibit the IL-3 but not the IL-6 response. These data are evidence of two pathways of signal transduction.
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