Immunological Responses to a Murine Mammary Adenocarcinoma
作者:
Yasuhiro Yamamura,
期刊:
Oncology
(Karger Available online 1980)
卷期:
Volume 37,
issue 1
页码: 6-11
ISSN:0030-2414
年代: 1980
DOI:10.1159/000225391
出版商: S. Karger AG
关键词: Arming;ADCC;Cytolysis;Monocytes
数据来源: Karger
摘要:
Serum from DBA/2J mice bearing a syngeneic T1699 mammary adenocarcinoma contains not only a specific antitumor antibody but also another factor(s) which arm normal monocytes in vitro and transform them into specific killer cells. Arming of normal monocytes by the factor(s) was inhibited by cytochalasin B and dactinomycin but not by mitomycin C. The ADCC activity of monocytes was at least partially resistant to the action of dactinomycin but cytotoxicity of armed effectors was totally blocked by the same drug. Effective cytolysis by armed monocytes required at least 5–6 h of continuous contact between the target and effector cells; and cytotoxicity could be reversed by cytochalasin B during this perio
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