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ACUTE TOLERANCE TO DIAZEPAM INDUCED BY BENZODIAZEPINES

 

作者: P. T. ‐H. Wong,   Y. L. Yoong,   M. C. E. Gwee,  

 

期刊: Clinical and Experimental Pharmacology and Physiology  （WILEY Available online 1986）
卷期: Volume 13, issue 1  

页码: 1-8

 

ISSN:0305-1870

 

年代: 1986

 

DOI:10.1111/j.1440-1681.1986.tb00309.x

 

出版商: Blackwell Publishing Ltd

 

关键词: acute tolerance;benzodiazepines;diazepam;hypnotic effect.

 

数据来源: WILEY

 

摘要:

SUMMARY1. It was observed that the effectiveness of diazepam in causing sleep, as denned by the loss of righting reflex, was significantly decreased after a single exposure to either diazepam or lorazepam.2. RO 15‐1788, a benzodiazepine antagonist, in contrast did not induce tolerance to diazepam. The mechanism for this acute tolerance is unclear. The rapidity in its development may exclude metabolic tolerance while alterations in brain sensitivity to diazepam remain a possibilit

 

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