Human Renin Granules: Ultrastructural Aspects
作者:
Giorgio Zavagli,
Arrigo Aleotti,
Alberto Farinelli,
期刊:
Nephron
(Karger Available online 1983)
卷期:
Volume 33,
issue 1
页码: 29-33
ISSN:1660-8151
年代: 1983
DOI:10.1159/000182900
出版商: S. Karger AG
关键词: Human renin granules;Electron microscopy;Juxtaglomerular apparatus
数据来源: Karger
摘要:
The ultrastructure of human renin granules has been studied from a case of Bartter’s syndrome. Renin bodies present roundish (R), lobulated (L) or sharply angulated (SA) shapes. The latter are indicative of the highest rates of renin synthesis and thereby of the greatest concentrations of the pressor enzyme. Their singular shape is consistent with the form monoclinic crystals assume when they grow in an isotropic medium. R granules form owing to filling of Golgian vesicles by renin. R bodies may then coalesce for giving rise to transient L forms. Renin is released through leak from the containing granules into the intracellular spac
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