Human mitotic and meiotic chromosome damage following in vivo exposure to methotrexate
作者:
John Melnyk,
David M. Duffy,
Robert S. Sparkes,
期刊:
Clinical Genetics
(WILEY Available online 1971)
卷期:
Volume 2,
issue 1
页码: 28-31
ISSN:0009-9163
年代: 1971
DOI:10.1111/j.1399-0004.1971.tb00251.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Mitotic chromosome damage was found in bone marrow cells but not in cultured lymphocytes or fibroblasts from a patient receiving methotrexate for treatment of psoriasis. No meiotic chromosome damage was detected in a testicular biopsy taken at the same time. These findings suggest that a full, definitive evaluation of human chromosome damage following drug exposure may require examination of several different tissues.
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