Measures of Skeletal Muscle Calcium Channels and Acetylcholine Receptors in Thyroidectomized Rats
作者:
KragieLaura,
SmiehorowskiRichard,
期刊:
Endocrine Research
(Taylor Available online 1993)
卷期:
Volume 19,
issue 2-3
页码: 207-219
ISSN:0743-5800
年代: 1993
DOI:10.3109/07435809309033025
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Hypothyroidism frequently presents with muscle complaints. No consistent histopathology nor electrophysiology explains these symptoms and signs. As well, no previous study shows specific changes in components of the nerve-muscle synapse nor excitation-contraction coupling in adult muscles, but changes are seen in hormone-treated embryonic myoblasts. In this study, adult male Holtzman rats underwent thyroidectomy and their age-matched euthyroid controls were simultaneously subjected to sham operation. Thirty days post-operative, animals were sacrificed for anterior tibialis muscles harvest. Muscle dihydropyridine type calcium channel (isradipine) and acetylcholine receptor ($aL-bungarotoxin) binding were measured and compared between experimental treatment groups. There were no significant differences in either the affinity or density of isradipine binding. However, hypothyroid muscles showed a nearly 50% reduction in acetylcholine receptor density when compared to control muscles. Thyroidectomy is associated with specific effects on components of neuromuscular transmission in adult fast twitch muscle.
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