Dynamic heterogeneity and metastasis
作者:
V. Ling,
A. F. Chambers,
J. F. Harris,
R. P. Hill,
期刊:
Journal of Cellular Physiology
(WILEY Available online 1984)
卷期:
Volume 121,
issue S3
页码: 99-103
ISSN:0021-9541
年代: 1984
DOI:10.1002/jcp.1041210412
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractParallel clonal populations grown to small defined sizes were used to quantitate rates of generation of metastatic cells. In murine KHT fibrosarcoma and B16 melanoma lines, metastatic cells are generated at effective rates of 10−5per cell per generation, or greater. These variant cells are unstable, and are apparently lost at very high rates. It thus appears that metastases could arise from unstable variants, and that rapid rates of change in some phenotypes may be an important feature of malignant progression. We have called such rapid variationsdynamic heterogeneity.This may be a useful concept for further investigating aspects of tumor heterogeneit
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