Opposite roles of D1 and D5 dopamine receptors in locomotion revealed by selective antisense oligonucleotides
作者:
Gustavo Dziewczapolski,
Liliana Menalled,
María García,
Marcelo Mora,
Oscar Gershanik,
Marcelo Rubinstein,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 1
页码: 1-5
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Antisense oligodeoxynucleotide;D1 dopamine receptor;D5 dopamine receptor;Locomotor activity;6-OHDA-lesioned rat
数据来源: OVID
摘要:
CONTRALATERAL rotations induced by the D1-like agonist SKF 38393 in unilaterally 6-hydroxydopamine-lesioned rats were completely prevented by the administration of the D1-like antagonist SCH 23390. A similar result was obtained after intracerebroventricular administration of an antisense oligodeoxynucleotide for the D1 receptor (D1R-as). Contrariwise, administration of a D5R-as potentiated the effects of SKF 38393, showing a 60% increase in the rotational scores. Both effects were reversible upon cessation of D1R-as or D5R-as treatment and were also specific since rotational scores in rats treated with vehicle or with a randomly designed oligodeoxynucleotide were not modified. These results suggest that whereas D1 receptors play a facilitatory role in locomotion, D5 receptors exert an inhibitory effect.
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