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Prostaglandin E2–Induced Inhibition of the In Vitro Immune Response by SRBC-Stimulated Human Lymphocytes

 

作者: MisefariA.,   ValentiA.,   CavallaroA.,   SofoV.,   SantarpiaG.,   SalmeriF. M.,   TetiD. Venza,  

 

期刊: Immunopharmacology and Immunotoxicology  （Taylor Available online 1991）
卷期: Volume 13, issue 1-2  

页码: 169-181

 

ISSN:0892-3973

 

年代: 1991

 

DOI:10.3109/08923979109019698

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

AbstractExogenous PGE2 strongly inhibits the response of human lymphocyte cultures to SRBC. This effect is mediated through a T cell inhibition since non-T cells are not significantly affected. Indomethacin, which inhibits in this system lymphocyte endogenous PGE2 synthesis increases the in vitro immune response. the effect of indomethacin is overcame by exogenous PGE2. These data may be relevant for explaining the immunomodulatory role of PGE2 following antigen challenge.

 

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