Immunoglobulin heavy chain class switch from IgM to IgG in a hybridoma
作者:
Pallaiah Thammana,
Matthew D. Scharff,
期刊:
European Journal of Immunology
(WILEY Available online 1983)
卷期:
Volume 13,
issue 8
页码: 614-619
ISSN:0014-2980
年代: 1983
DOI:10.1002/eji.1830130803
出版商: WILEY‐VCH Verlag GmbH
数据来源: WILEY
摘要:
AbstractA subclone of an IgM‐producing hybridoma has been identified which has switched to producing an IgG1antibody. The parent hybridoma, PC‐140, produces an antibody which binds phosphorylcholine and reacts with monoclonal antibodies that recognize myelomas of the T‐15 idiotype. The IgG1antibody binds phosphorylcholine with the same affinity as the parental IgM and also reacts with the anti‐T‐15 monoclonal antibodies. While the IgM‐producing parent hybridoma does not express detectable surface IgM, the IgG1‐producing subclone produces both membrane and
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