Combination Chemotherapy in the Treatment of Follicular Low-Grade Lymphoma
作者:
MorrisonVicki A.,
PetersonBruce A.,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 10,
issue sup1
页码: 29-33
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309149108
出版商: Taylor&Francis
关键词: Combination chemotherapy;follicular lymphoma;low-grade lymphoma
数据来源: Taylor
摘要:
The therapeutic approach to patients with follicular low-grade non-Hodgkin's lymphoma is controversial and has varied over a wide spectrum. A“watch and wait”approach in asymptomatic patients has been taken in some studies. In other series, single agent therapy with alkylating agents as cy-clophosphamide or chlorambucil has been employed. Response rates including complete responses are high, but relapses inevitably occur. Three-drug combination chemotherapy regimens consisting of cyclophosphamide, vincristine, and prednisone (CVP) have been utilized, in addition to more intensive regimens consisting of four or more drugs. Although responses are commonly achieved, there is no consistent survival advantage conferred by these more aggressive regimens. However, the remission duration may be prolonged in some subsets of patients as those with follicular mixed lymphoma. Due to the prolonged natural history of follicular low-grade lymphoma, a long period of follow-up is necessary to adequately evaluate the impact of a therapeutic regimen on remission duration and overall survival. Future trials may employ more aggressive therapy in combination with growth factors or biologic response modifiers in an effort to improve the outcome of patients with follicular low-grade lymphoma.
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