Influence of organic acids on aluminium absorption and storage in rat tissues
作者:
G. Testolin,
D. Erba,
S. Ciappellano,
G. Bermano,
期刊:
Food Additives & Contaminants
(Taylor Available online 1996)
卷期:
Volume 13,
issue 1
页码: 21-27
ISSN:0265-203X
年代: 1996
DOI:10.1080/02652039609374378
出版商: Taylor & Francis Group
关键词: aluminium;tissue depositions;organic acid;rat
数据来源: Taylor
摘要:
Six groups of 16 rats each were fed a standard diet for 8 weeks. Aluminium (Al) complexed with organic anions (citrate, lactate, malate or tartrate) was added to the diet of four of the groups and aluminium hydroxide to the diet of one group (control ‘Al +'). Aluminium concentrations in the diets were 1500–2000 mg/kg. The sixth group (control ‘Al ‐ ‘) served as control. Plasma, bone (femur), kidneys, cerebral cortex and cerebellum levels of aluminium were determined at 4 and 8 weeks. All the complexing agents increased tissue accumulations, compared with values in the two control groups, especially citrate in bone and kidneys and lactate in cerebral cortex. There were no significant differences (P< 0.05) in aluminium levels in the tissues considered between the ‘Al +’ and ‘Al ‐ ‘ control groups. Our results show the ability of dietary organic acids to increase aluminium absorption and tissue accumulation and indicate that concurrent intake of aluminium and dietary organic acids is not appropriate.
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