Synthesis of Two Tumor-Associated Oligosaccharides: Di- and Trifucosylated Para-Lacto-N-Hexaose
作者:
Stinabritt Nilsson,
Hans Lönn,
Thomas Norberg,
期刊:
Journal of Carbohydrate Chemistry
(Taylor Available online 1991)
卷期:
Volume 10,
issue 6
页码: 1023-1048
ISSN:0732-8303
年代: 1991
DOI:10.1080/07328309108543970
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Di- and trifucosylated derivatives (21 and 22) of para-lacto-N-hexaose were synthesized. Both structures have been shown to be present in small quantities in human milk, and have also been indicated as tumor-associated antigens. Thioglycoside mono- and disaccharide blocks were used to assemble a properly protected linear hexaose. Di- and trifucosylation at appropriate positions followed by deprotection then gave the desired oligosaccharides.
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