The Pyruvate Kinase Isoenzyme Shift in Human Gliomas: A potential marker in the treatment of gliomas
作者:
Van VeelenCees W. M.,
RijksenGert,
Van KetelB. A.,
StaalGerard E. J.,
期刊:
British Journal of Neurosurgery
(Taylor Available online 1988)
卷期:
Volume 2,
issue 2
页码: 257-263
ISSN:0268-8697
年代: 1988
DOI:10.3109/02688698808992677
出版商: Taylor&Francis
关键词: Cerebral glioma;pyruvate kinase;isoenzyme shift
数据来源: Taylor
摘要:
In primary human brain tumours a shift occurs in the synthesis of isoenzymes of pyruvate kinase from the M towards the K-type. In astrocytomas, oligodendrogliomas and glioblastomas, which were localised in the cerebral hemispheres of adult patients over 20 years of age, the shift correlated well with histological grading and growth rate as observed in postoperative survival. Gliomas of adults, localised in midline structures, as well as childrens gliomas were characterised too by a strong shift from M towards the K type. However, in these tumours, less correlation with histological grading and growth rate was found.The isoenzyme shift can be rapidly demonstrated with an alanine inhibition test. The application of this assay may have a diagnostic value during operation for gliomas in grading of malignancy in adults as well as demarcation of the resection of gliomas in all age groups. The test can be performed within 10–15 min and can thus fit easily into a surgical procedure. A case report is presented for illustration.
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